Neurobiology of Disease CCR2 Ly6C Inflammatory Monocyte Recruitment Exacerbates Acute Disability Following Intracerebral Hemorrhage
نویسندگان
چکیده
Matthew D. Hammond,1 Roslyn A. Taylor,2 Michael T. Mullen,3 Youxi Ai,1 Hector L. Aguila,2 Matthias Mack,4 Scott E. Kasner,3 Louise D. McCullough,1,5 and Lauren H. Sansing1,5,6 1Department of Neuroscience and 2Department of Immunology, University of Connecticut Health Center, Farmington, Connecticut 06030, 3Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, 4Department of Internal Medicine II, University Hospital Regensberg, 93053 Regensberg, Germany, and 5Department of Neurology and 6Department of Neurosurgery, Hartford Hospital, Hartford, Connecticut 06102
منابع مشابه
CX3CR1 Signaling on Monocytes Is Dispensable after Intracerebral Hemorrhage
Intracerebral hemorrhage is a subset of stroke for which there is no specific treatment. The Ly6Chi CCR2+ monocytes have been shown to contribute to acute injury after intracerebral hemorrhage. The other murine monocyte subset expresses CX3CR1 and lower Ly6C levels, and contributes to repair in other disease models. We hypothesized that the Ly6Clo CX3CR1+ monocytes would contribute to recovery ...
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